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Therapeutic Effect of Exendin-4, a Long-Acting Analogue of Glucagon-Like Peptide-1 Receptor Agonist, on Nerve Regeneration after the Crush Nerve Injury
Joint Authors
Yamamoto, Koji
Amako, Masatoshi
Yamamoto, Yoritsuna
Tsuchihara, Toyokazu
Nukada, Hitoshi
Yoshihara, Yasuo
Arino, Hiroshi
Fujita, Masanori
Uenoyama, Maki
Tachibana, Shoichi
Nemoto, Koichi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glucagon-like peptide-1 (GLP-1) is glucose-dependent insulinotropic hormone secreted from enteroendocrine L cells.
Its long-acting analogue, exendin-4, is equipotent to GLP-1 and is used to treat type 2 diabetes mellitus.
In addition, exendin-4 has effects on the central and peripheral nervous system.
In this study, we administered repeated intraperitoneal (i.p.) injections of exendin-4 to examine whether exendin-4 is able to facilitate the recovery after the crush nerve injury.
Exendin-4 injection was started immediately after crush injury and was repeated every day for subsequent 14 days.
Rats subjected to sciatic nerve crush exhibited marked functional loss, electrophysiological dysfunction, and atrophy of the tibialis anterior muscle (TA).
All these changes, except for the atrophy of TA, were improved significantly by the administration of exendin-4.
Functional, electrophysiological, and morphological parameters indicated significant enhancement of nerve regeneration 4 weeks after nerve crush.
These results suggest that exendin-4 is feasible for clinical application to treat peripheral nerve injury.
American Psychological Association (APA)
Yamamoto, Koji& Amako, Masatoshi& Yamamoto, Yoritsuna& Tsuchihara, Toyokazu& Nukada, Hitoshi& Yoshihara, Yasuo…[et al.]. 2013. Therapeutic Effect of Exendin-4, a Long-Acting Analogue of Glucagon-Like Peptide-1 Receptor Agonist, on Nerve Regeneration after the Crush Nerve Injury. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003995
Modern Language Association (MLA)
Yamamoto, Koji…[et al.]. Therapeutic Effect of Exendin-4, a Long-Acting Analogue of Glucagon-Like Peptide-1 Receptor Agonist, on Nerve Regeneration after the Crush Nerve Injury. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003995
American Medical Association (AMA)
Yamamoto, Koji& Amako, Masatoshi& Yamamoto, Yoritsuna& Tsuchihara, Toyokazu& Nukada, Hitoshi& Yoshihara, Yasuo…[et al.]. Therapeutic Effect of Exendin-4, a Long-Acting Analogue of Glucagon-Like Peptide-1 Receptor Agonist, on Nerve Regeneration after the Crush Nerve Injury. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003995