Is There a Causal Link between Inflammation and Dementia?
Joint Authors
Popescu, Bogdan Ovidiu
Enciu, Ana-Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neuroinflammation is a constant event in Alzheimer’s disease (AD), but the current knowledge is insufficient to state whether inflammation is a cause, a promoter, or simply a secondary phenomenon in this inexorably progressive ailment.
In the current paper, we review research data showing that inflammation is not a prerequisite for onset of dementia, and, although it may worsen the course of the disease, recent evidence shows that chronic inhibition of inflammatory pathways is not necessarily beneficial for patients.
Prospective clinical trials with anti-inflammatory drugs failed to stop disease progression, measurements of inflammatory markers in serum and cerebrospinal fluid of patients yielded contradictory results, and recent bench research proved undoubtedly that neuroinflammation has a protective side as well.
Knockout animal models for TNFRs or ILRs do not seem to prevent the pathology or the cognitive decline, but quite the contrary.
In AD, the therapeutic intervention on inflammatory pathways still has a research future, but its targets probably need reevaluation.
American Psychological Association (APA)
Enciu, Ana-Maria& Popescu, Bogdan Ovidiu. 2013. Is There a Causal Link between Inflammation and Dementia?. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004003
Modern Language Association (MLA)
Enciu, Ana-Maria& Popescu, Bogdan Ovidiu. Is There a Causal Link between Inflammation and Dementia?. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004003
American Medical Association (AMA)
Enciu, Ana-Maria& Popescu, Bogdan Ovidiu. Is There a Causal Link between Inflammation and Dementia?. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004003