Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females
Joint Authors
Shahid, Adeela
Rana, Sobia
Saeed, Shahid
Imran, Muhammad
Afzal, Nasir
Mahmood, Saqib
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations.
However, studies in Asian populations revealed conflicting results.
We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population.
Body weight, height, waist circumference, hip circumference, and blood pressure (BP) were measured.
BMI and waist-to-hip ratio (WHR) were calculated.
Levels of fasting blood glucose (FBG), insulin, leptin, and leptin receptors were measured by enzyme linked immunosorbent assay (ELISA), and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated.
The results showed association of FTO gene, rs9939609, with obesity in females (>18 years of age).
FTO minor allele increased the risk of obesity by 2.8 times (95% CI = 1.3–6.0) in females.
This allele showed association with body weight, BMI, waist circumference, hip circumference, WHR, BP, plasma FBG levels, HOMA-IR, plasma insulin levels, and plasma leptin levels.
In conclusion, FTO gene, rs9939609, is associated with BMI and risk of obesity in adult Pakistani females.
Association of rs9939609 variant with higher FBG, plasma insulin, and leptin levels indicates that this polymorphism may disturb the metabolism in adult females and predispose them to obesity and type 2 diabetes.
However, the above-mentioned findings were not seen in children or males.
American Psychological Association (APA)
Shahid, Adeela& Rana, Sobia& Saeed, Shahid& Imran, Muhammad& Afzal, Nasir& Mahmood, Saqib. 2013. Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004024
Modern Language Association (MLA)
Shahid, Adeela…[et al.]. Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004024
American Medical Association (AMA)
Shahid, Adeela& Rana, Sobia& Saeed, Shahid& Imran, Muhammad& Afzal, Nasir& Mahmood, Saqib. Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004024