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Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis
Joint Authors
Norton, Harry James
Hanley, Edward N.
Mauerhan, David R.
Gruber, Helen E.
Sun, Yubo
Franklin, Atiya M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Phosphocitrate (PC), a calcification inhibitor, inhibits the development of crystal-associated osteoarthritis (OA) in Hartley guinea pigs.
However, the molecular mechanisms underlying its disease-modifying effect remain elusive.
This study sought to test the hypothesis that PC has calcium crystal-independent biological activities which are, at least in part, responsible for its disease-modifying activity.
We found that PC inhibited the proliferation of OA fibroblast-like synoviocytes in the absence of calcium crystals.
Consistent with its effect on cell proliferation, PC downregulated the expression of numerous genes classified in cell proliferation.
PC also downregulated the expression of many genes classified in angiogenesis and inflammatory response including prostaglandin-endoperoxide synthase 2, interleukin-1 receptor, type I, and chemokine (C-C motif) ligand 2.
In contrast, PC upregulated the expression of many genes classified in musculoskeletal tissue development, including aggrecan, type I collagen, and insulin-like growth factor binding protein 5.
These findings suggest that PC is not only a promising disease-modifying drug for crystal-associated OA but also for noncrystal-associated OA.
American Psychological Association (APA)
Sun, Yubo& Mauerhan, David R.& Franklin, Atiya M.& Norton, Harry James& Hanley, Edward N.& Gruber, Helen E.. 2013. Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004029
Modern Language Association (MLA)
Sun, Yubo…[et al.]. Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004029
American Medical Association (AMA)
Sun, Yubo& Mauerhan, David R.& Franklin, Atiya M.& Norton, Harry James& Hanley, Edward N.& Gruber, Helen E.. Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004029