Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy
Joint Authors
Qiu, Jie
Zhou, Xiao-yu
Zhou, Xiao-guang
Cheng, Rui
Liu, Hai-ying
Li, Yong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
|Objectives.
To reveal the effect of microRNA-210 on cell apoptosis caused by HIE.
Methods.
Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline.
72 h after the injection, rats were sacrificed and the left hemispheres were collected.
The expression level of microRNA-210 was identified by quantitative real-time PCR analysis.
Apoptosis in brain sections was investigated by TUNEL assay.
Apoptosis-related protein expressions were studied by Western blot analysis.
Results.
The results showed that microRNA-210, whose expression was downregulated in the brain 72 h after HI injury, suppressed neuronal apoptosis by inhibiting caspase activity and regulating the balance between bcl-2 and bax levels.
Discussion.
Recent study demonstrated that microRNA-210 has neuroprotective effects through inhibiting apoptosis in a murine model of HIE.
It represents a potential novel therapeutic approach for the treatment of HIE.
American Psychological Association (APA)
Qiu, Jie& Zhou, Xiao-yu& Zhou, Xiao-guang& Cheng, Rui& Liu, Hai-ying& Li, Yong. 2013. Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004085
Modern Language Association (MLA)
Qiu, Jie…[et al.]. Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1004085
American Medical Association (AMA)
Qiu, Jie& Zhou, Xiao-yu& Zhou, Xiao-guang& Cheng, Rui& Liu, Hai-ying& Li, Yong. Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004085