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Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications
Joint Authors
Ishima, Yu
Kragh-Hansen, Ulrich
Maruyama, Toru
Otagiri, Masaki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Nitric oxide (NO) is a ubiquitous molecule involved in multiple cellular functions.
Inappropriate production of NO may lead to disease states.
To date, pharmacologically active compounds that release NO within the body, such as organic nitrates, have been used as therapeutic agents, but their efficacy is significantly limited by unwanted side effects.
Therefore, novel NO donors with better pharmacological and pharmacokinetic properties are highly desirable.
The S-nitrosothiol fraction in plasma is largely composed of endogenous S-nitrosated human serum albumin (Mono-SNO-HSA), and that is why we are testing whether this albumin form can be therapeutically useful.
Recently, we developed SNO-HSA analogs such as SNO-HSA with many conjugated SNO groups (Poly-SNO-HSA) which were prepared using chemical modification.
Unexpectedly, we found striking inverse effects between Poly-SNO-HSA and Mono-SNO-HSA.
Despite the fact that Mono-SNO-HSA inhibits apoptosis, Poly-SNO-HSA possesses very strong proapoptotic effects against tumor cells.
Furthermore, Poly-SNO-HSA can reduce or perhaps completely eliminate the multidrug resistance often developed by cancer cells.
In this review, we forward the possibility that Poly-SNO-HSA can be used as a safe and effective multifunctional antitumor agent.
American Psychological Association (APA)
Ishima, Yu& Kragh-Hansen, Ulrich& Maruyama, Toru& Otagiri, Masaki. 2013. Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004095
Modern Language Association (MLA)
Ishima, Yu…[et al.]. Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004095
American Medical Association (AMA)
Ishima, Yu& Kragh-Hansen, Ulrich& Maruyama, Toru& Otagiri, Masaki. Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004095