The Possible Role of Mena Protein and Its Splicing-Derived Variants in Embryogenesis, Carcinogenesis, and Tumor Invasion: A Systematic Review of the Literature
Joint Authors
Gurzu, Simona
Ciortea, Diana
Ember, Istvan
Jung, Ioan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The Ena/VASP (enabled/vasodilator stimulated phosphoprotein) family includes the binding actin proteins such as mammalian Ena (Mena), VASP, and Ena-VASP-like.
It is known that the perturbation of actin cycle could determine alteration in the mobility of cells and in consequence of organogenesis.
Few recent studies have revealed that Mena protein could play a role in breast or pancreatic carcinogenesis.
Based on our researches, we observed that the intensity of Mena expression increased from premalignant to malignant lesions in some organs such as large bowel, stomach, cervix, and salivary glands.
These findings prove that Mena could be a marker of premalignant epithelial lesions.
In premalignant lesions, it could be helpful to define more accurately the risk for malignant transformation.
In malignant tumors, correlation of expression of its splice variants could indicate metastatic behavior.
In conclusion, we consider that it is necessary to analyze the expression of Mena splice variants in a higher number of cases, in different epithelial lesions, and also in experimental studies to define its exact role in carcinogenesis and also its possible prognostic and predictive values.
American Psychological Association (APA)
Gurzu, Simona& Ciortea, Diana& Ember, Istvan& Jung, Ioan. 2013. The Possible Role of Mena Protein and Its Splicing-Derived Variants in Embryogenesis, Carcinogenesis, and Tumor Invasion: A Systematic Review of the Literature. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004117
Modern Language Association (MLA)
Gurzu, Simona…[et al.]. The Possible Role of Mena Protein and Its Splicing-Derived Variants in Embryogenesis, Carcinogenesis, and Tumor Invasion: A Systematic Review of the Literature. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004117
American Medical Association (AMA)
Gurzu, Simona& Ciortea, Diana& Ember, Istvan& Jung, Ioan. The Possible Role of Mena Protein and Its Splicing-Derived Variants in Embryogenesis, Carcinogenesis, and Tumor Invasion: A Systematic Review of the Literature. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004117