PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy
Joint Authors
Nagasaka, Kazunori
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cervical cancer is caused by high-risk human papillomaviruses (HPVs), and a unique characteristic of these is a PDZ (P̲SD-95/D̲lg/Z̲O-1-)binding motif in their E6 proteins.
Through this motif HPV E6 interacts with a variety of PDZ domain-containing proteins and targets them mainly for degradation.
These E6-PDZ interactions exhibit extraordinarily different functions in relation to HPV-induced malignancy, depending upon various cellular contexts; for example, Dlg and Scrib show different distribution patterns from what is seen in normal epithelium, both in localization and in amount, and their loss may be a late-stage marker in malignant progression.
Recent studies show that interactions with specific forms of the proteins may have oncogenic potential.
In addition, it is interesting that PDZ proteins make a contribution to the stabilization of E6 and viral episomal maintenance during the course of HPV life cycle.
Various posttranslational modifications also greatly affect their functions.
Phosphorylation of hDlg and hScrib by certain kinases regulates several important signaling cascades, and E6-PDZ interactions themselves are regulated through PKA-dependent phosphorylation.
Thus these interactions naturally have great potential for both predictive and therapeutic applications, and, with development of screening tools for identifying novel targets of their interactions, comprehensive spatiotemporal analysis is currently underway.
American Psychological Association (APA)
Nagasaka, Kazunori& Kawana, Kei& Osuga, Yutaka& Fujii, Tomoyuki. 2013. PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004122
Modern Language Association (MLA)
Nagasaka, Kazunori…[et al.]. PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004122
American Medical Association (AMA)
Nagasaka, Kazunori& Kawana, Kei& Osuga, Yutaka& Fujii, Tomoyuki. PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004122