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No Immunogenicity of IPS Cells in Syngeneic Host Studied by In Vivo Injection and 3D Scaffold Experiments
Joint Authors
Nishio, Naomi
Cheng, Zhao
Thanasegaran, Suganya
Isobe, Ken-ichi
Ito, Sachiko
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Induced Pluripotent Stem Cells (IPSCs) open the great possibility to employ patient’s own tissue to the previously incurable diseases.
However these cells can be used in cell therapy only if they are not rejected when transplanted back into the syngeneic host.
We found that the injection of iPSCs derived from different ages of mice into syngeneic C57BL/6 mice produced teratoma and was not rejected.
Then we cultured iPSCs and myeloid differentiated iPSCs in three-dimensional porous scaffold and transplanted to C57BL/6 mice and BALB/C mice.
After transplantation, we could observe the cell density inside the scaffold increased rapidly in syngeneic mice compared to the allogeneic mice indicating the favorable conditions supporting the growth of iPSCs in vivo.
Unlike the allogeneic counterpart, we could not observe few infiltrating T cells inside the scaffold of syngeneic mice.
These results contribute to the optimistic view of iPSCs for regenerative medicine in near future.
American Psychological Association (APA)
Thanasegaran, Suganya& Cheng, Zhao& Ito, Sachiko& Nishio, Naomi& Isobe, Ken-ichi. 2013. No Immunogenicity of IPS Cells in Syngeneic Host Studied by In Vivo Injection and 3D Scaffold Experiments. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004144
Modern Language Association (MLA)
Thanasegaran, Suganya…[et al.]. No Immunogenicity of IPS Cells in Syngeneic Host Studied by In Vivo Injection and 3D Scaffold Experiments. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004144
American Medical Association (AMA)
Thanasegaran, Suganya& Cheng, Zhao& Ito, Sachiko& Nishio, Naomi& Isobe, Ken-ichi. No Immunogenicity of IPS Cells in Syngeneic Host Studied by In Vivo Injection and 3D Scaffold Experiments. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004144