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Enhanced Therapeutic Efficacy of iRGD-Conjugated Crosslinked Multilayer Liposomes for Drug Delivery
Joint Authors
Liu, Yarong
Ji, Man
Wong, Michael K.
Joo, Kye-Il
Wang, Pin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Targeting nanoparticles by conjugating various specific ligands has shown potential therapeutic efficacy in nanomedicine.
However, poor penetration of antitumor drugs into solid tumors remains a major obstacle.
Here, we describe a targeting strategy for antitumor drug delivery by conjugating a crosslinked multilamellar liposomal vesicle (cMLV) formulation with a tumor-penetrating peptide, iRGD.
The results showed that iRGD peptides could facilitate the binding and cellular uptake of drug-loaded cMLVs and consequently enhance the antitumor efficacy in breast tumor cells, including multidrug-resistant cells.
Moreover, colocalization data revealed that iRGD-conjugated cMLVs (iRGD-cMLVs) entered cells via the clathrin-mediated pathway, followed by endosome-lysosome transport for efficient drug delivery.
Finally, in vivo study indicated that iRGD-cMLVs could deliver anticancer drugs efficiently to mediate significant tumor suppression.
American Psychological Association (APA)
Liu, Yarong& Ji, Man& Wong, Michael K.& Joo, Kye-Il& Wang, Pin. 2013. Enhanced Therapeutic Efficacy of iRGD-Conjugated Crosslinked Multilayer Liposomes for Drug Delivery. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004145
Modern Language Association (MLA)
Liu, Yarong…[et al.]. Enhanced Therapeutic Efficacy of iRGD-Conjugated Crosslinked Multilayer Liposomes for Drug Delivery. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004145
American Medical Association (AMA)
Liu, Yarong& Ji, Man& Wong, Michael K.& Joo, Kye-Il& Wang, Pin. Enhanced Therapeutic Efficacy of iRGD-Conjugated Crosslinked Multilayer Liposomes for Drug Delivery. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004145