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Propagation of Adult SSCs: From Mouse to Human
Joint Authors
Martin, Laura A.
Seandel, Marco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adult spermatogonial stem cells (SSCs) represent a distinctive source of stem cells in mammals for several reasons.
First, by giving rise to spermatogenesis, SSCs are responsible for the propagation of a father’s genetic material.
As such, autologous SSCs have been considered for treatment of infertility and other purposes, including correction of inherited disorders.
Second, adult spermatogonia can spontaneously produce embryonic-like stem cells in vitro, which could be used as an alternative for therapeutic, diagnostic, or drug discovery strategies for humans.
Therefore, an increasing urgency is driving efforts to understand the biology of SSCs and improve techniques to manipulate them in vitro as a prerequisite to achieve the aforementioned goals.
The characterization of adult SSCs also requires reproducible methods to isolate and maintain them in long-term culture.
Herein, we describe recent major advances and challenges in propagation of adult SSCs from mice and humans during the past few years, including the use of unique cell surface markers and defined cultured conditions.
American Psychological Association (APA)
Martin, Laura A.& Seandel, Marco. 2013. Propagation of Adult SSCs: From Mouse to Human. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004156
Modern Language Association (MLA)
Martin, Laura A.& Seandel, Marco. Propagation of Adult SSCs: From Mouse to Human. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004156
American Medical Association (AMA)
Martin, Laura A.& Seandel, Marco. Propagation of Adult SSCs: From Mouse to Human. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004156