History, Pathogenesis, and Management of Familial Gastric Cancer: Original Study of John XXIII's Family
Joint Authors
Corso, Giovanni
Roncalli, Fabrizio
Marrelli, Daniele
Carneiro, Fátima
Roviello, Franco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hereditary diffuse gastric cancer is associated with the E-cadherin germline mutations, but genetic determinants have not been identified for familial intestinal gastric carcinoma.
The guidelines for hereditary diffuse gastric cancer are clearly established; however, there are no defined recommendations for the management of familial intestinal gastric carcinoma.
Methods.
In this study we describe Pope John XXIII's pedigree that harboured gastric cancer as well as six other family members.
Family history was analysed according to the International Gastric Cancer Linkage Consortium criteria, and gastric tumours were classified in accord with the last Japanese guidelines.
Results.
Seven out of 109 members in this pedigree harboured gastric cancer, affecting two consecutive generations.
John XXIII's clinical tumour (cTN) was classified as cT4bN3a (IV stage).
In two other cases, gastric carcinomas were classified as intestinal histotype and staged as pT1bN0 and pT2N2, respectively.
Conclusions.
Pope John XXIII's family presents a strong aggregation for gastric cancer affecting almost seven members; it spreads through two consecutive generations.
In absence of defined genetic causes and considering the increased risk of gastric cancer’s development in these families, as well as the high mortality rates and advanced stages, we propose an intensive surveillance protocol for asymptomatic members.
American Psychological Association (APA)
Corso, Giovanni& Roncalli, Fabrizio& Marrelli, Daniele& Carneiro, Fátima& Roviello, Franco. 2012. History, Pathogenesis, and Management of Familial Gastric Cancer: Original Study of John XXIII's Family. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004159
Modern Language Association (MLA)
Corso, Giovanni…[et al.]. History, Pathogenesis, and Management of Familial Gastric Cancer: Original Study of John XXIII's Family. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004159
American Medical Association (AMA)
Corso, Giovanni& Roncalli, Fabrizio& Marrelli, Daniele& Carneiro, Fátima& Roviello, Franco. History, Pathogenesis, and Management of Familial Gastric Cancer: Original Study of John XXIII's Family. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004159