![](/images/graphics-bg.png)
Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation
Joint Authors
Yongcharoen, Sasitorn
Rattanasiri, Sasivimol
McDaniel, D. Olga
McEvoy, Mark
Viwatwongkaseam, Chukiat
Rojanavipart, Piangchan
Thakkinstian, Ammarin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We performed a systematic review and meta-analysis with the aim of assessing the association between cytokine gene polymorphisms and graft rejection in heart transplantation.
We identified relevant studies from Medline and Embase using PubMed and Ovid search engines, respectively.
Allele frequencies and allele and genotypic effects were pooled.
Heterogeneity and publication bias were explored.
Four to 5 studies were included in pooling of 3 gene polymorphisms.
The prevalences of the minor alleles for TNFα-308, TGFβ1-c10, and TGFβ1-c25 were 0.166 (95% CI: 0.129, 0.203), 0.413 (95% CI: 0.363, 0.462), and 0.082 (95% CI: 0.054, 0.111) in the control groups, respectively.
Carrying the A allele for the TNFα-308 had 18% (95% CI of OR: 0.46, 3.01) increased risk, but this was not significant for developing graft rejection than the G allele.
Conversely, carrying the minor alleles for both TGFβ1-c10 and c25 had nonsignificantly lower odds of graft rejection than major alleles, with the pooled ORs of 0.87 (95% CI: 0.65, 1.18) and 0.70 (95% CI: 0.40, 1.23), respectively.
There was no evidence of publication bias for all poolings.
An updated meta-analysis is required when more studies are published to increase the power of detection for the association between these polymorphisms and allograft rejection.
American Psychological Association (APA)
Yongcharoen, Sasitorn& Rattanasiri, Sasivimol& McDaniel, D. Olga& McEvoy, Mark& Viwatwongkaseam, Chukiat& Rojanavipart, Piangchan…[et al.]. 2013. Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004165
Modern Language Association (MLA)
Yongcharoen, Sasitorn…[et al.]. Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004165
American Medical Association (AMA)
Yongcharoen, Sasitorn& Rattanasiri, Sasivimol& McDaniel, D. Olga& McEvoy, Mark& Viwatwongkaseam, Chukiat& Rojanavipart, Piangchan…[et al.]. Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004165