A Comparative Analysis of Biomarker Selection Techniques
Joint Authors
Dessì, Nicoletta
Pascariello, Emanuele
Pes, Barbara
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Feature selection has become the essential step in biomarker discovery from high-dimensional genomics data.
It is recognized that different feature selection techniques may result in different set of biomarkers, that is, different groups of genes highly correlated to a given pathological condition, but few direct comparisons exist which quantify these differences in a systematic way.
In this paper, we propose a general methodology for comparing the outcomes of different selection techniques in the context of biomarker discovery.
The comparison is carried out along two dimensions: (i) measuring the similarity/dissimilarity of selected gene sets; (ii) evaluating the implications of these differences in terms of both predictive performance and stability of selected gene sets.
As a case study, we considered three benchmarks deriving from DNA microarray experiments and conducted a comparative analysis among eight selection methods, representatives of different classes of feature selection techniques.
Our results show that the proposed approach can provide useful insight about the pattern of agreement of biomarker discovery techniques.
American Psychological Association (APA)
Dessì, Nicoletta& Pascariello, Emanuele& Pes, Barbara. 2013. A Comparative Analysis of Biomarker Selection Techniques. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004168
Modern Language Association (MLA)
Dessì, Nicoletta…[et al.]. A Comparative Analysis of Biomarker Selection Techniques. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004168
American Medical Association (AMA)
Dessì, Nicoletta& Pascariello, Emanuele& Pes, Barbara. A Comparative Analysis of Biomarker Selection Techniques. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004168