Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2
Joint Authors
Zouari-Kessentini, Raoudha
Srairi-Abid, Najet
Bazaa, Amine
El Ayeb, Mohamed
Luis, Jose
Marrakchi, Naziha
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Phospholipases type A2 (PLA2s) are the most abundant proteins found in Viperidae snake venom.
They are quite fascinating from both a biological and structural point of view.
Despite similarity in their structures and common catalytic properties, they exhibit a wide spectrum of pharmacological activities.
Besides being hydrolases, secreted phospholipases A2 (sPLA2) are an important group of toxins, whose action at the molecular level is still a matter of debate.
These proteins can display toxic effects by different mechanisms.
In addition to neurotoxicity, myotoxicity, hemolytic activity, antibacterial, anticoagulant, and antiplatelet effects, some venom PLA2s show antitumor and antiangiogenic activities by mechanisms independent of their enzymatic activity.
This paper aims to discuss original finding against anti-tumor and anti-angiogenic activities of sPLA2 isolated from Tunisian vipers: Cerastes cerastes and Macrovipera lebetina, representing new tools to target specific integrins, mainly, α5β1 and αv integrins.
American Psychological Association (APA)
Zouari-Kessentini, Raoudha& Srairi-Abid, Najet& Bazaa, Amine& El Ayeb, Mohamed& Luis, Jose& Marrakchi, Naziha. 2013. Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004189
Modern Language Association (MLA)
Zouari-Kessentini, Raoudha…[et al.]. Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004189
American Medical Association (AMA)
Zouari-Kessentini, Raoudha& Srairi-Abid, Najet& Bazaa, Amine& El Ayeb, Mohamed& Luis, Jose& Marrakchi, Naziha. Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004189