![](/images/graphics-bg.png)
Interleukin-13 +1923CT Polymorphism Is Associated with Asthma Risk: A Meta-Analysis
Joint Authors
Liu, Yongan
Liu, Tao
Nie, Wei
Lai, Guoxiang
Xiu, Qingyu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma.
We performed this study to assess the association by the method of meta-analysis.
A systematic search current to October 16, 2012, was conducted using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) and identified ten studies comprising 13698 cases and 38209 controls.
The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
There was a significant association between IL-13 +1923C/T polymorphism and asthma risk in codominant model.
When stratified by ethnicity, IL-13 +1923C/T polymorphism remained significantly associated with higher asthma risk in Asians and Caucasians.
In the subgroup analysis by study quality, a significantly increased asthma risk was observed in high quality studies.
Sensitivity analysis and cumulative analysis further strengthened the validity of the results.
No publication bias was found in this meta-analysis.
In conclusion, results from this meta-analysis suggested that IL-13 +1923C/T polymorphism was a risk factor of asthma.
American Psychological Association (APA)
Liu, Yongan& Liu, Tao& Nie, Wei& Lai, Guoxiang& Xiu, Qingyu. 2013. Interleukin-13 +1923CT Polymorphism Is Associated with Asthma Risk: A Meta-Analysis. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004203
Modern Language Association (MLA)
Liu, Yongan…[et al.]. Interleukin-13 +1923CT Polymorphism Is Associated with Asthma Risk: A Meta-Analysis. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004203
American Medical Association (AMA)
Liu, Yongan& Liu, Tao& Nie, Wei& Lai, Guoxiang& Xiu, Qingyu. Interleukin-13 +1923CT Polymorphism Is Associated with Asthma Risk: A Meta-Analysis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004203