Molecular and Survival Differences between Familial and Sporadic Gastric Cancers
Joint Authors
Fang, Wen-Liang
Chang, Shih-Ching
Lan, Yuan-Tzu
Huang, Kuo-Hung
Lo, Su-Shun
Li, Anna Fen-Yau
Chi, Chin-Wen
Wu, Chew-Wun
Chiou, Shih Hwa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mismatch repair (MMR) and germline E-cadherin (CDH1) mutations are two of the major pathways of carcinogenesis in familial gastric cancer (GC).
A total of 260 sporadic and 66 familial GC patients were enrolled and molecular and survival differences were compared.
Familial GC patients had earlier onset and were diagnosed at an earlier stage and had both a better 5-year overall survival rate and 3-year disease-free survival rate compared with sporadic GC patients.
Only in diffuse type GC, the MSI-H phenotype and abnormal MMR protein expression were significantly higher in familial GC than in sporadic GC.
In MSI-H GC, MLH1 promoter methylation was slightly higher in sporadic GC than familial GC (50% versus 23.1%), while the frequency of MMR gene mutation was slightly higher in familial GC than in sporadic GC (15.4% versus 3.1%).
All of the patients with MMR gene mutation had diffuse type GC.
Among familial GC patients with CDH1 mutation, most patients (72.3%) had diffuse type GC.
In summary, for familial GC patients, we recommend screening of MSI status and CDH1 mutation especially for diffuse type GC.
Because of the low incidence, mutation analysis of MMR gene might be considered in MSI-H familial GC with diffuse type only.
American Psychological Association (APA)
Fang, Wen-Liang& Chang, Shih-Ching& Lan, Yuan-Tzu& Huang, Kuo-Hung& Lo, Su-Shun& Li, Anna Fen-Yau…[et al.]. 2013. Molecular and Survival Differences between Familial and Sporadic Gastric Cancers. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004206
Modern Language Association (MLA)
Fang, Wen-Liang…[et al.]. Molecular and Survival Differences between Familial and Sporadic Gastric Cancers. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004206
American Medical Association (AMA)
Fang, Wen-Liang& Chang, Shih-Ching& Lan, Yuan-Tzu& Huang, Kuo-Hung& Lo, Su-Shun& Li, Anna Fen-Yau…[et al.]. Molecular and Survival Differences between Familial and Sporadic Gastric Cancers. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004206