The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis
Joint Authors
Dodič-Fikfak, Metoda
Arnerić, Niko
Franko, Alenka
Dolžan, Vita
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis.
The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorphisms.
Data on cumulative asbestos and smoking were available for all subjects.
To assess gene-gene and gene-environmental interactions, logistic regression was used.
The associations between MnSOD Ala −9Val polymorphism and the risk of asbestosis and between iNOS genotypes and asbestosis were modified by CAT –262 C > T polymorphism (P=0.038;P=0.031).
A strong interaction was found between GSTM1-null polymorphism and smoking (P=0.007), iNOS (CCTTT)n polymorphism and smoking (P=0.054), and between iNOS (CCTTT)n polymorphism and cumulative asbestos exposure (P=0.037).
The findings of this study suggest that the interactions between different genotypes, genotypes and smoking, and between genotypes and asbestos exposure have an important influence on the development of asbestosis and should be seriously considered in future research on occupational/environmental asbestos-related diseases.
American Psychological Association (APA)
Franko, Alenka& Dolžan, Vita& Arnerić, Niko& Dodič-Fikfak, Metoda. 2013. The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004230
Modern Language Association (MLA)
Franko, Alenka…[et al.]. The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004230
American Medical Association (AMA)
Franko, Alenka& Dolžan, Vita& Arnerić, Niko& Dodič-Fikfak, Metoda. The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004230