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Deregulation of the miRNAs Expression in Cervical Cancer: Human Papillomavirus Implications
Joint Authors
Gómez-Gómez, Yazmín
Organista-Nava, Jorge
Gariglio, Patricio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a class of small non coding RNAs of 18–25 nucleotides in length.
The temporal or short-lived expression of the miRNAs modulates gene expression post transcriptionally.
Studies have revealed that miRNAs deregulation correlates and is involved with the initiation and progression of human tumors.
Cervical cancer (CC) displays notably increased or decreased expression of a large number of cellular oncogenic or tumor suppressive miRNAs, respectively.
However, understanding the potential role of miRNAs in CC is still limited.
In CC, the high-risk human papillomaviruses (HR-HPVs) infection can affect the miRNAs expression through oncoprotein E6 and E7 that contribute to viral pathogenesis, although other viral proteins might also be involved.
This deregulation in the miRNAs expression has an important role in the hallmarks of CC.
Interestingly, the miRNA expression profile in CC can discriminate between normal and tumor tissue and the extraordinary stability of miRNAs makes it suitable to serve as diagnostic and prognostic biomarkers of cancer.
In this review, we will summarize the role of the HR-HPVs in miRNA expression, the role of miRNAs in the hallmarks of CC, and the use of miRNAs as potential prognostic biomarkers in CC.
American Psychological Association (APA)
Gómez-Gómez, Yazmín& Organista-Nava, Jorge& Gariglio, Patricio. 2013. Deregulation of the miRNAs Expression in Cervical Cancer: Human Papillomavirus Implications. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004235
Modern Language Association (MLA)
Gómez-Gómez, Yazmín…[et al.]. Deregulation of the miRNAs Expression in Cervical Cancer: Human Papillomavirus Implications. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1004235
American Medical Association (AMA)
Gómez-Gómez, Yazmín& Organista-Nava, Jorge& Gariglio, Patricio. Deregulation of the miRNAs Expression in Cervical Cancer: Human Papillomavirus Implications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004235