Postoperative Adiponectin Levels in Pediatric Patients Undergoing Open Heart Surgery
Joint Authors
Thaler, A.
Kanety, H.
Avni, T.
Mishali, D.
Hemi, R.
Yissaschar, E.
Pariente, C.
Paret, G.
Modan-Moses, D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Adipose tissue is an important endocrine organ that secretes cytokines, including adiponectin, levels of which are negatively correlated with the severity of the inflammatory process.
Aim.
To assess the time course of adiponectin levels following open heart surgery with cardiopulmonary bypass and its correlation with early postoperative outcomes.
Materials and Methods.
Blood samples were obtained from 24 children undergoing cardiac surgery and analyzed for adiponectin, C-reactive protein, and other inflammatory markers.
Results.
Baseline adiponectin levels were negatively correlated with patients’ preoperative weight and age.
Postoperative adiponectin levels decreased compared to baseline (P=0.01) and correlated negatively with duration of cardiopulmonary bypass (r=-0.438, P=0.037), length of stay in the pediatric intensive care unit (r=-0.457, P=0.025), and the inotropic score (r=-0.471, P=0.02).
Adiponectin levels were positively correlated with sVCAM 1 levels; however, there was no correlation between adiponectin levels and sP selectin, tPA, MCP1, and sCD40.
Conclusions.
The inflammatory response after open heart surgery with cardiopulmonary bypass is associated with a reduction in adiponectin levels.
Prolonged or more complicated surgery induced a more substantial inflammatory process characterized by a significant reduction in adiponectin levels over time and a delayed return to baseline levels.
American Psychological Association (APA)
Thaler, A.& Kanety, H.& Avni, T.& Mishali, D.& Hemi, R.& Yissaschar, E.…[et al.]. 2013. Postoperative Adiponectin Levels in Pediatric Patients Undergoing Open Heart Surgery. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004244
Modern Language Association (MLA)
Thaler, A.…[et al.]. Postoperative Adiponectin Levels in Pediatric Patients Undergoing Open Heart Surgery. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004244
American Medical Association (AMA)
Thaler, A.& Kanety, H.& Avni, T.& Mishali, D.& Hemi, R.& Yissaschar, E.…[et al.]. Postoperative Adiponectin Levels in Pediatric Patients Undergoing Open Heart Surgery. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004244