Expression Pattern of Genes of RLR-Mediated Antiviral Pathway in Different-Breed Chicken Response to Marek’s Disease Virus Infection
Joint Authors
Feng, Ze-Qing
Lian, Ting
Huang, Yong
Liu, Yi-Ping
Zhu, Qing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It has been known that the chicken’s resistance to disease was affected by chicken’s genetic background.
And RLR-mediated antiviral pathway plays an important role in detection of viral RNA.
However, little is known about the interaction of genetic background with RLR-mediated antiviral pathway in chicken against MDV infection.
In this study, we adopted economic line-AA broilers and native Erlang mountainous chickens for being infected with MDV.
Upon infection with MDV, the expression of MDA-5 was upregulated in two-breed chickens at 4, 7, and 21 d.p.i.
It is indicated that MDA-5 might be involved in detecting MDV in chicken.
Interestingly, the expression of IRF-3 and IFN-β genes was decreased in spleen and thymus of broilers at 21 d.p.i, but it was upregulated in immune tissues of Erlang mountainous chickens.
And the genome load of MDV in spleen of broiler is significantly higher than that in Erlang mountainous chickens.
Meanwhile, we observed that the death of broiler mainly also occurred in this phase.
Collectively, these present results demonstrated that the expression patters of IRF-3 and IFN-β genes in chicken against MDV infection might be affected by the genetic background which sequently influence the resistance of chicken response to MDV.
American Psychological Association (APA)
Feng, Ze-Qing& Lian, Ting& Huang, Yong& Zhu, Qing& Liu, Yi-Ping. 2013. Expression Pattern of Genes of RLR-Mediated Antiviral Pathway in Different-Breed Chicken Response to Marek’s Disease Virus Infection. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004271
Modern Language Association (MLA)
Feng, Ze-Qing…[et al.]. Expression Pattern of Genes of RLR-Mediated Antiviral Pathway in Different-Breed Chicken Response to Marek’s Disease Virus Infection. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004271
American Medical Association (AMA)
Feng, Ze-Qing& Lian, Ting& Huang, Yong& Zhu, Qing& Liu, Yi-Ping. Expression Pattern of Genes of RLR-Mediated Antiviral Pathway in Different-Breed Chicken Response to Marek’s Disease Virus Infection. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004271