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Role of STAT3 in Cancer Metastasis and Translational Advances
Joint Authors
Kamran, Mohammad Zahid
Patil, Prachi
Gude, Rajiv P.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor, originally discovered as a transducer of signal from cell surface receptors to the nucleus.
It is activated by tyrosine phosphorylation at position 705 leading to its dimerization, nuclear translocation, DNA binding, and activation of gene transcription.
Under normal physiological conditions, STAT3 activation is tightly regulated.
However, compelling evidence suggests that STAT3 is constitutively activated in many cancers and plays a pivotal role in tumor growth and metastasis.
It regulates cellular proliferation, invasion, migration, and angiogenesis that are critical for cancer metastasis.
In this paper, we first describe the mechanism of STAT3 regulation followed by how STAT3 is involved in cancer metastasis, then we summarize the various small molecule inhibitors that inhibit STAT3 signaling.
American Psychological Association (APA)
Kamran, Mohammad Zahid& Patil, Prachi& Gude, Rajiv P.. 2013. Role of STAT3 in Cancer Metastasis and Translational Advances. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004279
Modern Language Association (MLA)
Kamran, Mohammad Zahid…[et al.]. Role of STAT3 in Cancer Metastasis and Translational Advances. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1004279
American Medical Association (AMA)
Kamran, Mohammad Zahid& Patil, Prachi& Gude, Rajiv P.. Role of STAT3 in Cancer Metastasis and Translational Advances. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004279