Full-Length Genomic Sequence of Subgenotype IIIA Hepatitis A Virus Isolate in Republic of Korea
Joint Authors
Lee, Ah-Ra
Lee, Sung-Geun
Kang, Lae-Hyung
Jheong, Weon-Hwa
Paik, Soon-Young
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatitis A virus is known to cause acute hepatitis and has significant implications for public health throughout the world.
In the Republic of Korea, the number of patients with hepatitis A virus infection has been increasing rapidly since 2006.
In this study, the Kor-HAV-F strain was identified as subgenotype IIIA by RT-PCR, and its identity was confirmed by nucleotide sequencing and alignment analysis.
Moreover, detailed phylogenetic analysis indicated that the Kor-HAV-F strain clustered into subgenotype IIIA, including strains isolated in Japan, Norway, and India.
The entire amino acid sequence of the VP1 and 2A regions was compared with that of the reference strains isolated in various countries.
We found 2 amino acid changes (T168A and L96P, resp.) in the VP1 and 2A regions, which had not been found in any other hepatitis A virus strain.
To our knowledge, this study is the first to report the full-length sequence of a hepatitis A virus isolated in the Republic of Korea.
American Psychological Association (APA)
Lee, Ah-Ra& Lee, Sung-Geun& Kang, Lae-Hyung& Jheong, Weon-Hwa& Paik, Soon-Young. 2013. Full-Length Genomic Sequence of Subgenotype IIIA Hepatitis A Virus Isolate in Republic of Korea. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004286
Modern Language Association (MLA)
Lee, Ah-Ra…[et al.]. Full-Length Genomic Sequence of Subgenotype IIIA Hepatitis A Virus Isolate in Republic of Korea. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004286
American Medical Association (AMA)
Lee, Ah-Ra& Lee, Sung-Geun& Kang, Lae-Hyung& Jheong, Weon-Hwa& Paik, Soon-Young. Full-Length Genomic Sequence of Subgenotype IIIA Hepatitis A Virus Isolate in Republic of Korea. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004286