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Fibrinogen-Induced Streptococcus mutans Biofilm Formation and Adherence to Endothelial Cells
Joint Authors
Bedran, Telma Blanca
Azelmat, Jabrane
Grenier, Daniel
Palomari Spolidorio, Denise Madalena
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Streptococcus mutans, the predominant bacterial species associated with dental caries, can enter the bloodstream and cause infective endocarditis.
The aim of this study was to investigate S.
mutans biofilm formation and adherence to endothelial cells induced by human fibrinogen.
The putative mechanism by which biofilm formation is induced as well as the impact of fibrinogen on S.
mutans resistance to penicillin was also evaluated.
Bovine plasma dose dependently induced biofilm formation by S.
mutans.
Of the various plasma proteins tested, only fibrinogen promoted the formation of biofilm in a dose-dependent manner.
Scanning electron microscopy observations revealed the presence of complex aggregates of bacterial cells firmly attached to the polystyrene support.
S.
mutans in biofilms induced by the presence of fibrinogen was markedly resistant to the bactericidal effect of penicillin.
Fibrinogen also significantly increased the adherence of S.
mutans to endothelial cells.
Neither S.
mutans cells nor culture supernatants converted fibrinogen into fibrin.
However, fibrinogen is specifically bound to the cell surface of S.
mutans and may act as a bridging molecule to mediate biofilm formation.
In conclusion, our study identified a new mechanism promoting S.
mutans biofilm formation and adherence to endothelial cells which may contribute to infective endocarditis.
American Psychological Association (APA)
Bedran, Telma Blanca& Azelmat, Jabrane& Palomari Spolidorio, Denise Madalena& Grenier, Daniel. 2013. Fibrinogen-Induced Streptococcus mutans Biofilm Formation and Adherence to Endothelial Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004298
Modern Language Association (MLA)
Bedran, Telma Blanca…[et al.]. Fibrinogen-Induced Streptococcus mutans Biofilm Formation and Adherence to Endothelial Cells. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004298
American Medical Association (AMA)
Bedran, Telma Blanca& Azelmat, Jabrane& Palomari Spolidorio, Denise Madalena& Grenier, Daniel. Fibrinogen-Induced Streptococcus mutans Biofilm Formation and Adherence to Endothelial Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004298