Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction
Joint Authors
Rodrigo, Ramón
Libuy, Matías
Feliú, Felipe
Hasson, Daniel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Acute myocardial infarction (AMI) is the leading cause of mortality worldwide.
Major advances in the treatment of acute coronary syndromes and myocardial infarction, using cardiologic interventions, such as thrombolysis or percutaneous coronary angioplasty (PCA) have improved the clinical outcome of patients.
Nevertheless, as a consequence of these procedures, the ischemic zone is reperfused, giving rise to a lethal reperfusion event accompanied by increased production of reactive oxygen species (oxidative stress).
These reactive species attack biomolecules such as lipids, DNA, and proteins enhancing the previously established tissue damage, as well as triggering cell death pathways.
Studies on animal models of AMI suggest that lethal reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.
Although a number of strategies have been aimed at to ameliorate lethal reperfusion injury, up to date the beneficial effects in clinical settings have been disappointing.
The use of antioxidant vitamins could be a suitable strategy with this purpose.
In this review, we propose a systematic approach to the molecular basis of the cardioprotective effect of antioxidant vitamins in myocardial ischemia-reperfusion injury that could offer a novel therapeutic opportunity against this oxidative tissue damage.
American Psychological Association (APA)
Rodrigo, Ramón& Libuy, Matías& Feliú, Felipe& Hasson, Daniel. 2013. Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004309
Modern Language Association (MLA)
Rodrigo, Ramón…[et al.]. Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1004309
American Medical Association (AMA)
Rodrigo, Ramón& Libuy, Matías& Feliú, Felipe& Hasson, Daniel. Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004309