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Immunobiologic and Antiinflammatory Properties of a Bark Extract from Ampelozizyphus amazonicus Ducke
Joint Authors
Peçanha, Ligia Maria Torres
Fernandes, Patricia Dias
Simen, Tatiana Jotha-Mattos
Oliveira, Danilo Ribeiro de
Finotelli, Priscilla Vanessa
Pereira, Marina Vieira Agostinho
Barboza, Fernanda Ferreira
Almeida, Thays da Silva
Carvalhal, Stephanie
Pierucci, Anna Paola Trindade Rocha
Leitão, Gilda Guimarães
Rastrelli, Luca
Piccinelli, Anna Lisa
Leitão, Suzana Guimarães
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ampelozizyphus amazonicus is used in the treatment and prevention of malaria.
The effect of an aqueous extract from this plant (SART) on the immune response was investigated by measuring immunoglobulin production induced by immunization with the antigen TNP-Ficoll in Plasmodium chabaudi-infected mice.
SART treatment increased antigen-specific IgM and IgG levels in TNP-Ficoll-immunized mice.
The B cell response during malarial infection was also modified by SART.
There was an increase in total serum IgM and IgG and a decrease in the percentage of splenic plasma cells (CD138+ cells) in P.
chabaudi-infected, SART-treated animals.
SART (1, 3 or 10 mg/kg, p.o.) and the reference drug dexamethasone (5 mg/kg) were also tested in carrageenan-induced leukocyte migration to the subcutaneous air pouch (SAP).
All SART doses significantly reduced leukocyte migration into the SAP.
The protein concentration resulting from extravasation into the peritoneum was also significantly reduced.
Our data indicate that SART possesses immunomodulatory properties, inducing an in vivo modification of the B lymphocyte response and anti-inflammatory properties, which are partly due to a reduction in cell migration and are most likely due to an inhibition of the production of inflammatory mediators.
Preliminary HPLC-ESI-MS/MS analysis of SART shows a complex saponin profile with deprotonated molecule [M-H]− ions in the range of m/z 800–1000.
American Psychological Association (APA)
Peçanha, Ligia Maria Torres& Fernandes, Patricia Dias& Simen, Tatiana Jotha-Mattos& Oliveira, Danilo Ribeiro de& Finotelli, Priscilla Vanessa& Pereira, Marina Vieira Agostinho…[et al.]. 2013. Immunobiologic and Antiinflammatory Properties of a Bark Extract from Ampelozizyphus amazonicus Ducke. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004316
Modern Language Association (MLA)
Peçanha, Ligia Maria Torres…[et al.]. Immunobiologic and Antiinflammatory Properties of a Bark Extract from Ampelozizyphus amazonicus Ducke. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004316
American Medical Association (AMA)
Peçanha, Ligia Maria Torres& Fernandes, Patricia Dias& Simen, Tatiana Jotha-Mattos& Oliveira, Danilo Ribeiro de& Finotelli, Priscilla Vanessa& Pereira, Marina Vieira Agostinho…[et al.]. Immunobiologic and Antiinflammatory Properties of a Bark Extract from Ampelozizyphus amazonicus Ducke. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004316