Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification
Joint Authors
Sun, Jingchun
Zhao, Min
Fanous, Ayman H.
Zhao, Zhongming
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Antipsychotic drugs are medications commonly for schizophrenia (SCZ) treatment, which include two groups: typical and atypical.
SCZ patients have multiple comorbidities, and the coadministration of drugs is quite common.
This may result in adverse drug-drug interactions, which are events that occur when the effect of a drug is altered by the coadministration of another drug.
Therefore, it is important to provide a comprehensive view of these interactions for further coadministration improvement.
Here, we extracted SCZ drugs and their adverse drug interactions from the DrugBank and compiled a SCZ-specific adverse drug interaction network.
This network included 28 SCZ drugs, 241 non-SCZs, and 991 interactions.
By integrating the Anatomical Therapeutic Chemical (ATC) classification with the network analysis, we characterized those interactions.
Our results indicated that SCZ drugs tended to have more adverse drug interactions than other drugs.
Furthermore, SCZ typical drugs had significant interactions with drugs of the “alimentary tract and metabolism” category while SCZ atypical drugs had significant interactions with drugs of the categories “nervous system” and “antiinfectives for systemic uses.” This study is the first to characterize the adverse drug interactions in the course of SCZ treatment and might provide useful information for the future SCZ treatment.
American Psychological Association (APA)
Sun, Jingchun& Zhao, Min& Fanous, Ayman H.& Zhao, Zhongming. 2013. Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004328
Modern Language Association (MLA)
Sun, Jingchun…[et al.]. Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004328
American Medical Association (AMA)
Sun, Jingchun& Zhao, Min& Fanous, Ayman H.& Zhao, Zhongming. Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004328