Vasculoprotective Effects of Combined Endothelial Progenitor Cells and Mesenchymal Stem Cells in Diabetic Wound Care: Their Potential Role in Decreasing Wound-Oxidative Stress
Joint Authors
Patumraj, Suthiluk
Sukpat, Supakanda
Isarasena, Nipan
Wongphoom, Jutamas
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To investigate whether the combined endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) could enhance angiogenesis and wound healing in diabetic mice.
Balb/c nude mice were divided into five groups, including a control group, diabetic group (DM), DM injected with 1 × 106 cells MSCs, DM injected with 1 × 106 cells EPCs, and DM injected with combined 0.5 × 106 cells MSCs and 0.5 × 106 cells EPCs.
After seven weeks, the mice were anesthetized, and bilateral full-thickness excision skin wounds were made on the dorsorostral back.
The percentage of wound closure in DM group decreased significantly than in control and all other treated groups on day 7 and day 14 (P<0.005).
On day 14, the percentage of capillary vascularity in combine-treated group was significantly higher than in DM (P<0.005).
In the present study, we have demonstrated that the combined EPCs and MSCs can increase vascular endothelial growth factor (VEGF) level and angiogenesis which resulted in reduced neutrophil infiltration, decreased malondialdehyde (MDA) levels, and enhanced wound healing in diabetic mice model.
American Psychological Association (APA)
Sukpat, Supakanda& Isarasena, Nipan& Wongphoom, Jutamas& Patumraj, Suthiluk. 2013. Vasculoprotective Effects of Combined Endothelial Progenitor Cells and Mesenchymal Stem Cells in Diabetic Wound Care: Their Potential Role in Decreasing Wound-Oxidative Stress. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004332
Modern Language Association (MLA)
Sukpat, Supakanda…[et al.]. Vasculoprotective Effects of Combined Endothelial Progenitor Cells and Mesenchymal Stem Cells in Diabetic Wound Care: Their Potential Role in Decreasing Wound-Oxidative Stress. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004332
American Medical Association (AMA)
Sukpat, Supakanda& Isarasena, Nipan& Wongphoom, Jutamas& Patumraj, Suthiluk. Vasculoprotective Effects of Combined Endothelial Progenitor Cells and Mesenchymal Stem Cells in Diabetic Wound Care: Their Potential Role in Decreasing Wound-Oxidative Stress. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004332