Bleomycin Loaded Magnetite Nanoparticles Functionalized by Polyacrylic Acid as a New Antitumoral Drug Delivery System
Joint Authors
Xu, Yue
Lin, Yi
Zhuang, Lin
Lin, Jiong
Lv, Jiahong
Huang, Qin
Sun, Jiadong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
To prepare, characterize, and analyze the release behavior of bleomycin-loaded magnetite nanoparticles (BLM-MNPs) coated with polyacrylic acid (PAA) as a new drug delivery system that can be specifically distributed in the tumor site.
Methods.
BLM-MNPs coated with PAA were prepared using a solvothermal approach.
The particles were characterized using scanning electron microscope (SEM), vibrating sample magnetometer (VSM), and Fourier transform infrared spectroscopy (FTIR).
The loading and release behaviors of BLM-MNPs were examined by a mathematical formula and in vitro release profile at pH 7.5.
Results.
The sphere Fe3O4 nanoparticles with the size of approximately 30 nm exhibit a saturation magnetization of 87 emu/g.
The noncoordinated carboxylate groups of PAA confer on the good dispersibility in the aqueous solution and lead to a good loading efficiency of BLM reaching 50% or higher.
Approximately 98% of immobilized BLM could be released within 24 h, of which 22.4% was released in the first hour and then the remaining was released slowly and quantitatively in the next 23 hours.
Conclusion.
BLM-MNPs were prepared and characterized successfully.
The particles show high saturation magnetization, high drug loading capacity, and favorable release property, which could contribute to the specific delivery and controllable release of BLM, and the BLM-MNPs could be a potential candidate for the development of treating solid tumors.
American Psychological Association (APA)
Xu, Yue& Lin, Yi& Zhuang, Lin& Lin, Jiong& Lv, Jiahong& Huang, Qin…[et al.]. 2013. Bleomycin Loaded Magnetite Nanoparticles Functionalized by Polyacrylic Acid as a New Antitumoral Drug Delivery System. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004352
Modern Language Association (MLA)
Xu, Yue…[et al.]. Bleomycin Loaded Magnetite Nanoparticles Functionalized by Polyacrylic Acid as a New Antitumoral Drug Delivery System. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1004352
American Medical Association (AMA)
Xu, Yue& Lin, Yi& Zhuang, Lin& Lin, Jiong& Lv, Jiahong& Huang, Qin…[et al.]. Bleomycin Loaded Magnetite Nanoparticles Functionalized by Polyacrylic Acid as a New Antitumoral Drug Delivery System. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004352