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Highly Ordered Architecture of MicroRNA Cluster
Joint Authors
Shi, Bing
Zhu, Mingxuan
Liu, Shuang
Zhang, Mandun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights.
By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster.
A significant correlation between miRNA expression level and its placement was revealed.
More importantly, the placement of these miRNAs is associated with their dysregulation in cancer.
Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology.
American Psychological Association (APA)
Shi, Bing& Zhu, Mingxuan& Liu, Shuang& Zhang, Mandun. 2013. Highly Ordered Architecture of MicroRNA Cluster. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1004356
Modern Language Association (MLA)
Shi, Bing…[et al.]. Highly Ordered Architecture of MicroRNA Cluster. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1004356
American Medical Association (AMA)
Shi, Bing& Zhu, Mingxuan& Liu, Shuang& Zhang, Mandun. Highly Ordered Architecture of MicroRNA Cluster. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1004356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004356