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Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives
Joint Authors
Salam, Kazi Abdus
Akimitsu, Nobuyoshi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Currently, hepatitis C virus (HCV) infection is considered a serious health-care problem all over the world.
A good number of direct-acting antivirals (DAAs) against HCV infection are in clinical progress including NS3-4A protease inhibitors, RNA-dependent RNA polymerase inhibitors, and NS5A inhibitors as well as host targeted inhibitors.
Two NS3-4A protease inhibitors (telaprevir and boceprevir) have been recently approved for the treatment of hepatitis C in combination with standard of care (pegylated interferon plus ribavirin).
The new therapy has significantly improved sustained virologic response (SVR); however, the adverse effects associated with this therapy are still the main concern.
In addition to the emergence of viral resistance, other targets must be continually developed.
One such underdeveloped target is the helicase portion of the HCV NS3 protein.
This review article summarizes our current understanding of HCV treatment, particularly with those of NS3 inhibitors.
American Psychological Association (APA)
Salam, Kazi Abdus& Akimitsu, Nobuyoshi. 2013. Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004368
Modern Language Association (MLA)
Salam, Kazi Abdus& Akimitsu, Nobuyoshi. Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004368
American Medical Association (AMA)
Salam, Kazi Abdus& Akimitsu, Nobuyoshi. Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004368