Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats
Joint Authors
Bracht, Adelar
Peralta, Rosane Marina
Soares, Andréia A.
de Oliveira, Andrea L.
Sá-Nakanishi, Anacharis B.
Comar, Jurandir F.
Rampazzo, Ana P. S.
Vicentini, Fernando A.
Natali, Maria R. M.
Gomes da Costa, Sandra M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The action of an Agaricus blazei aqueous extract pretreatment on paracetamol injury in rats was examined not only in terms of the classical indicators (e.g., levels of hepatic enzymes in the plasma) but also in terms of functional and metabolic parameters (e.g., gluconeogenesis).
Considering solely the classical indicators for tissue damage, the results can be regarded as an indication that the A.
blazei extract is able to provide a reasonable degree of protection against the paracetamol injury in both the hepatic and brain tissues.
The A.
blazei pretreatment largely prevented the increased levels of hepatic enzymes in the plasma (ASP, ALT, LDH, and ALP) and practically normalized the TBARS levels in both liver and brain tissues.
With respect to the functional and metabolic parameters of the liver, however, the extract provided little or no protection.
This includes morphological signs of inflammation and the especially important functional parameter gluconeogenesis, which was impaired by paracetamol.
Considering these results and the long list of extracts and substances that are said to have hepatoprotective effects, it would be useful to incorporate evaluations of functional parameters into the experimental protocols of studies aiming to attribute or refute effective hepatoprotective actions to natural products.
American Psychological Association (APA)
Soares, Andréia A.& de Oliveira, Andrea L.& Sá-Nakanishi, Anacharis B.& Comar, Jurandir F.& Rampazzo, Ana P. S.& Vicentini, Fernando A.…[et al.]. 2013. Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004371
Modern Language Association (MLA)
Soares, Andréia A.…[et al.]. Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004371
American Medical Association (AMA)
Soares, Andréia A.& de Oliveira, Andrea L.& Sá-Nakanishi, Anacharis B.& Comar, Jurandir F.& Rampazzo, Ana P. S.& Vicentini, Fernando A.…[et al.]. Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004371