Chronic Alcohol Ingestion Changes the Landscape of the Alveolar Epithelium
Joint Authors
Downs, Charles A.
Trac, David
Brewer, Elizabeth M.
Brown, Lou Ann
Helms, My N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Similar to effects of alcohol on the heart, liver, and brain, the effects of ethanol (EtOH) on lung injury are preventable.
Unlike other vital organ systems, however, the lethal effects of alcohol on the lung are underappreciated, perhaps because there are no signs of overt pulmonary disorder until a secondary insult, such as a bacterial infection or injury, occurs in the lung.
This paper provides overview of the complex changes in the alveolar environment known to occur following both chronic and acute alcohol exposures.
Contemporary animal and cell culture models for alcohol-induced lung dysfunction are discussed, with emphasis on the effect of alcohol on transepithelial transport processes, namely, epithelial sodium channel activity (ENaC).
The cascading effect of tissue and phagocytic Nadph oxidase (Nox) may be triggered by ethanol exposure, and as such, alcohol ingestion and exposure lead to a prooxidative environment; thus impacting alveolar macrophage (AM) function and oxidative stress.
A better understanding of how alcohol changes the landscape of the alveolar epithelium can lead to improvements in treating acute respiratory distress syndrome (ARDS) for which hospitalized alcoholics are at an increased risk.
American Psychological Association (APA)
Downs, Charles A.& Trac, David& Brewer, Elizabeth M.& Brown, Lou Ann& Helms, My N.. 2012. Chronic Alcohol Ingestion Changes the Landscape of the Alveolar Epithelium. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004375
Modern Language Association (MLA)
Downs, Charles A.…[et al.]. Chronic Alcohol Ingestion Changes the Landscape of the Alveolar Epithelium. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004375
American Medical Association (AMA)
Downs, Charles A.& Trac, David& Brewer, Elizabeth M.& Brown, Lou Ann& Helms, My N.. Chronic Alcohol Ingestion Changes the Landscape of the Alveolar Epithelium. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004375