HGF Accelerates Wound Healing by Promoting the Dedifferentiation of Epidermal Cells through β1-IntegrinILK Pathway
Joint Authors
Li, Jin-Feng
Duan, Hai-Feng
Wu, Chu-Tse
Zhang, Da-Jin
Deng, Youping
Yin, Hong-Lei
Han, Bing
Gong, Hui-Cui
Wang, Hong-Wei
Wang, Yunliang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Skin wound healing is a critical and complex biological process after trauma.
This process is activated by signaling pathways of both epithelial and nonepithelial cells, which release a myriad of different cytokines and growth factors.
Hepatocyte growth factor (HGF) is a cytokine known to play multiple roles during the various stages of wound healing.
This study evaluated the benefits of HGF on reepithelialization during wound healing and investigated its mechanisms of action.
Gross and histological results showed that HGF significantly accelerated reepithelialization in diabetic (DB) rats.
HGF increased the expressions of the cell adhesion molecules β1-integrin and the cytoskeleton remodeling protein integrin-linked kinase (ILK) in epidermal cells in vivo and in vitro.
Silencing of ILK gene expression by RNA interference reduced expression of β1-integrin, ILK, and c-met in epidermal cells, concomitantly decreasing the proliferation and migration ability of epidermal cells.
β1-Integrin can be an important maker of poorly differentiated epidermal cells.
Therefore, these data demonstrate that epidermal cells become poorly differentiated state and regained some characteristics of epidermal stem cells under the role of HGF after wound.
Taken together, the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the β1-integrin/ILK pathway.
American Psychological Association (APA)
Li, Jin-Feng& Duan, Hai-Feng& Wu, Chu-Tse& Zhang, Da-Jin& Deng, Youping& Yin, Hong-Lei…[et al.]. 2013. HGF Accelerates Wound Healing by Promoting the Dedifferentiation of Epidermal Cells through β1-IntegrinILK Pathway. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004377
Modern Language Association (MLA)
Li, Jin-Feng…[et al.]. HGF Accelerates Wound Healing by Promoting the Dedifferentiation of Epidermal Cells through β1-IntegrinILK Pathway. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004377
American Medical Association (AMA)
Li, Jin-Feng& Duan, Hai-Feng& Wu, Chu-Tse& Zhang, Da-Jin& Deng, Youping& Yin, Hong-Lei…[et al.]. HGF Accelerates Wound Healing by Promoting the Dedifferentiation of Epidermal Cells through β1-IntegrinILK Pathway. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004377