Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene
Joint Authors
Sirivarasai, Jintana
Wananukul, Winai
Kaojarern, Sming
Chanprasertyothin, Suwannee
Thongmung, Nisakron
Ratanachaiwong, Wipa
Sura, Thanyachai
Sritara, Piyamit
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response.
In addition, modifying these toxic effects varied partly by GST polymorphism.
The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure.
The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR.
Means of blood lead and serum hs-CRP were 5.45 μg/dL and 2.07 mg/L.
Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48–24.63 μg/dL) compared with those in quartile 1 (1.23–3.47 μg/dL, P<0.01).
In particular, in men with blood lead >6.47 μg/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05–2.20), 1.32 (95% CI; 1.03–1.69), 1.65 (95% CI; 1.17–2.35), and 1.98 (95% CI; 1.47–2.55), respectively.
Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP.
GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response.
American Psychological Association (APA)
Sirivarasai, Jintana& Wananukul, Winai& Kaojarern, Sming& Chanprasertyothin, Suwannee& Thongmung, Nisakron& Ratanachaiwong, Wipa…[et al.]. 2013. Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004388
Modern Language Association (MLA)
Sirivarasai, Jintana…[et al.]. Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004388
American Medical Association (AMA)
Sirivarasai, Jintana& Wananukul, Winai& Kaojarern, Sming& Chanprasertyothin, Suwannee& Thongmung, Nisakron& Ratanachaiwong, Wipa…[et al.]. Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004388