Comparison of Stress-Hemoconcentration Correction Techniques for Stress-Induced Coagulation
Joint Authors
Austin, Anthony W.
Patterson, Stephen M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
When examining stress effects on coagulation, arithmetic correction is typically used to adjust for concomitant hemoconcentration but may be inappropriate for coagulation activity assays.
We examined a new physiologically relevant method of correcting for stress-hemoconcentration.
Blood was drawn from healthy men (N=40) during baseline, mental stress, and recovery, and factor VII activity (FVII:C), factor VIII activity (FVIII:C), activated partial thromboplastin time (APTT), prothrombin time (PT%), fibrinogen, D-dimer, and plasma volume were determined.
Three hemoconcentration correction techniques were assessed: arithmetic correction and two reconstitution techniques using baseline plasma or physiological saline.
Area-under-the-curve (AUC) was computed for each technique.
For FVII:C, uncorrected AUC was significantly greater than AUC corrected arithmetically.
For PT%, uncorrected AUC was significantly greater than AUC corrected with saline or arithmetically.
For APTT, uncorrected AUC was significantly less than AUC corrected with saline and greater than AUC corrected arithmetically.
For fibrinogen, uncorrected AUC was significantly greater than AUC corrected with saline or arithmetically.
For D-dimer, uncorrected AUC was significantly greater than AUC corrected arithmetically.
No differences in AUC were observed for FVIII:C.
Saline reconstitution seems most appropriate when adjusting for hemoconcentration effects on clotting time and activity.
Stress-hemoconcentration accounted for the majority of coagulation changes.
American Psychological Association (APA)
Austin, Anthony W.& Patterson, Stephen M.. 2013. Comparison of Stress-Hemoconcentration Correction Techniques for Stress-Induced Coagulation. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004411
Modern Language Association (MLA)
Austin, Anthony W.& Patterson, Stephen M.. Comparison of Stress-Hemoconcentration Correction Techniques for Stress-Induced Coagulation. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004411
American Medical Association (AMA)
Austin, Anthony W.& Patterson, Stephen M.. Comparison of Stress-Hemoconcentration Correction Techniques for Stress-Induced Coagulation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004411