Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus

Abstract EN

The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes.

We included, in this study, 149 patients with type 2 diabetes.

We evaluated their cardiovascular risk factors, demographic data, and any major micro- and macrovascular complications of their diabetes.

Assessments of CAN were based upon Ewing’s battery.

Results.

CAN was present in 38.9% of patients.

In the CAN group, the duration of diabetes, BMI, systolic blood pressure, lipid levels, and HBA1c were all significantly higher than those in the other group.

A significant association was found between CAN and retinopathy, peripheral neuropathy, ABI, and IMT.

Multivariate logistic regression demonstrated that, in type 2 diabetes, the odds of CAN (OR (95% confidence intervals)) increase with the age of the patients (1.68 (1,4129–2.0025)), the average diabetes duration (0.57 (0.47–0.67)), cholesterol (1.009 (1.00-1.01)), HbA1c levels (1.88 (1.31–2.72)), peripheral neuropathy (15.47 (5.16–46.38)), BMI (1.12 (1.05–1.21)), and smoking (2.21 (1.08–4.53)).

Conclusions.

This study shows that CAN in type 2 diabetes is significantly associated with other macro- and microvascular complications and that there are important modifiable risk factors for its development.