Improved Succinate Production by Metabolic Engineering
Joint Authors
Cheng, Ke-Ke
Wang, Gen-Yu
Zeng, Jing
Zhang, Jianan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Succinate is a promising chemical which has wide applications and can be produced by biological route.
The history of the biosuccinate production shows that the joint effort of different metabolic engineering approaches brings successful results.
In order to enhance the succinate production, multiple metabolical strategies have been sought.
In this review, different overproducers for succinate production, including natural succinate overproducers and metabolic engineered overproducers, are examined and the metabolic engineering strategies and performances are discussed.
Modification of the mechanism of substrate transportation, knocking-out genes responsible for by-products accumulation, overexpression of the genes directly involved in the pathway, and improvement of internal NADH and ATP formation are some of the strategies applied.
Combination of the appropriate genes from homologous and heterologous hosts, extension of substrate, integrated production of succinate, and other high-value-added products are expected to bring a desired objective of producing succinate from renewable resources economically and efficiently.
American Psychological Association (APA)
Cheng, Ke-Ke& Wang, Gen-Yu& Zeng, Jing& Zhang, Jianan. 2013. Improved Succinate Production by Metabolic Engineering. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004551
Modern Language Association (MLA)
Cheng, Ke-Ke…[et al.]. Improved Succinate Production by Metabolic Engineering. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004551
American Medical Association (AMA)
Cheng, Ke-Ke& Wang, Gen-Yu& Zeng, Jing& Zhang, Jianan. Improved Succinate Production by Metabolic Engineering. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004551