Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients
Joint Authors
Thomas, Peter
Iglhaut, Gerhard
Wollenberg, Andreas
Cadosch, Dieter
Summer, Burkhard
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypersensitivity reactions to titanium (Ti) are very rare.
Thus, we assessed the proinflammatory response and also potential tolerance favoring in vitro reactivity of human blood lymphocytes and monocytes (PBMC) to Ti in healthy individuals (14 without, 6 with complication-free dental Ti implants).
The proliferation index (SI) in lymphocyte transformation test (LTT) and production of cytokines linked to innate immune response (IL-1β, IL-6, and TNFα) or immune regulation (IL-10) were assessed in response to TiO2 particles or Ti discs.
In both groups, the Ti-LTT reactivity was not enhanced (e.g., SI<3).
The control antigen tetanus toxoid (TT) gave adequate reactivity (median SI individuals without/with implant: 20.6±5.97/19.58±2.99).
Individuals without implant showed higher cytokine response to Ti materials than individuals with symptom-free implants; for example, TiO2 rutile particle induced increase of IL-1β 70.27-fold/8.49-fold versus control medium culture.
PBMC of 5 of the 6 individuals with complication-free Ti implants showed an ex vivo ongoing production of IL-10 (mean 4.18±2.98 pg/mL)-but none of the 14 controls showed such IL-10 production.
Thus in vitro IL-1β-, IL-6-, and TNF-α production reflects “normal” unspecific immune response to Ti.
This might be reduced by production of tolerogenic IL-10 in individuals with symptom-free Ti dental implants.
American Psychological Association (APA)
Thomas, Peter& Iglhaut, Gerhard& Wollenberg, Andreas& Cadosch, Dieter& Summer, Burkhard. 2013. Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004555
Modern Language Association (MLA)
Thomas, Peter…[et al.]. Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004555
American Medical Association (AMA)
Thomas, Peter& Iglhaut, Gerhard& Wollenberg, Andreas& Cadosch, Dieter& Summer, Burkhard. Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004555