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Aminopeptidase N (CD13) Is Involved in Phagocytic Processes in Human Dendritic Cells and Macrophages
Joint Authors
Villaseñor-Cardoso, Mónica I.
Frausto-Del-Río, Dulce A.
Ortega, Enrique
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aminopeptidase N (APN or CD13) is a membrane ectopeptidase expressed by many cell types, including myelomonocytic lineage cells: monocytes, macrophages, and dendritic cells.
CD13 is known to regulate the biological activity of various peptides by proteolysis, and it has been proposed that CD13 also participates in several functions such as angiogenesis, cell adhesion, metastasis, and tumor invasion.
We had previously reported that, in human monocytes and macrophages, CD13 modulates the phagocytosis mediated by receptors for the Fc portion of IgG antibodies (FcγRs).
In this work, we analyzed the possible interaction of CD13 with other phagocytic receptors.
We found out that the cross-linking of CD13 positively modulates the phagocytosis mediated by receptors of the innate immune system, since a significant increase in the phagocytosis of zymosan particles or heat-killed E.
coli was observed when CD13 was cross-linked using anti-CD13 antibodies, in both macrophages and dendritic cells.
Also, we observed that, during the phagocytosis of zymosan, CD13 redistributes and is internalized into the phagosome.
These findings suggest that, besides its known functions, CD13 participates in phagocytic processes in dendritic cells and macrophages.
American Psychological Association (APA)
Villaseñor-Cardoso, Mónica I.& Frausto-Del-Río, Dulce A.& Ortega, Enrique. 2013. Aminopeptidase N (CD13) Is Involved in Phagocytic Processes in Human Dendritic Cells and Macrophages. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004591
Modern Language Association (MLA)
Villaseñor-Cardoso, Mónica I.…[et al.]. Aminopeptidase N (CD13) Is Involved in Phagocytic Processes in Human Dendritic Cells and Macrophages. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004591
American Medical Association (AMA)
Villaseñor-Cardoso, Mónica I.& Frausto-Del-Río, Dulce A.& Ortega, Enrique. Aminopeptidase N (CD13) Is Involved in Phagocytic Processes in Human Dendritic Cells and Macrophages. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004591