Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
Joint Authors
Macaluso, Fabio Salvatore
Maida, Marcello
Minissale, Maria Giovanna
Li Vigni, Teresa
Attardo, Simona
Orlando, Emanuele
Petta, Salvatore
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the last years, several lines of evidence showed how metabolic factors may influence the natural history of patients with chronic hepatitis C.
Chronic HCV infection is able to perturb the metabolic homeostasis of the host, in a context of complex interactions where pre-existent metabolic status and genetic background play an important role, allowing us to state that HCV infection is a systemic disease.
In this review, we discuss the most recent lines of evidence on the main metabolic factors that are known to be associated with CHC, namely, insulin resistance/type 2 diabetes, steatosis, visceral obesity, atherosclerosis, vitamin D, menopause, fructose and coffee intake, lipoproteins, methylenetetrahydrofolate reductase status, and hyperuricaemia.
In particular, we focus on the pathophysiological mechanisms underlying the correlation between HCV infection and metabolic disorders, the impact of metabolic factors on the progression of liver and non-liver-related diseases, and, on the contrary, the possible influence of chronic HCV infection on metabolic features.
In this setting, the importance of a multifaceted evaluation of CHC patients and a prompt correction of modifiable metabolic risk factors should be emphasized.
American Psychological Association (APA)
Maida, Marcello& Minissale, Maria Giovanna& Li Vigni, Teresa& Attardo, Simona& Orlando, Emanuele& Petta, Salvatore…[et al.]. 2013. Metabolic Factors and Chronic Hepatitis C: A Complex Interplay. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004600
Modern Language Association (MLA)
Maida, Marcello…[et al.]. Metabolic Factors and Chronic Hepatitis C: A Complex Interplay. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004600
American Medical Association (AMA)
Maida, Marcello& Minissale, Maria Giovanna& Li Vigni, Teresa& Attardo, Simona& Orlando, Emanuele& Petta, Salvatore…[et al.]. Metabolic Factors and Chronic Hepatitis C: A Complex Interplay. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004600