Synergistic Effects of Secretory Phospholipase A2 from the Venom of Agkistrodon piscivorus piscivorus with Cancer Chemotherapeutic Agents
Joint Authors
Nelson, Jennifer
Barlow, Kristen
Beck, D. Olin
Berbert, Amanda
Eshenroder, Nathan
Francom, Lyndee
Pruitt, Mark
Thompson, Kina
Thompson, Kyle
Thurber, Brian
Yeung, Celestine H.-Y.
Judd, Allan M.
Bell, John D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Healthy cells typically resist hydrolysis catalyzed by snake venom secretory phospholipase A2.
However, during various forms of programmed cell death, they become vulnerable to attack by the enzyme.
This observation raises the question of whether the specificity of the enzyme for dying cells could be used as a strategy to eliminate tumor cells that have been intoxicated but not directly killed by chemotherapeutic agents.
This idea was tested with S49 lymphoma cells and a broad range of antineoplastic drugs: methotrexate, daunorubicin, actinomycin D, and paclitaxel.
In each case, a substantial population of treated cells was still alive yet vulnerable to attack by the enzyme.
Induction of cell death by these agents also perturbed the biophysical properties of the membrane as detected by merocyanine 540 and trimethylammonium-diphenylhexatriene.
These results suggest that exposure of lymphoma cells to these drugs universally causes changes to the cell membrane that render it susceptible to enzymatic attack.
The data also argue that the snake venom enzyme is not only capable of clearing cell corpses but can aid in the demise of tumor cells that have initiated but not yet completed the death process.
American Psychological Association (APA)
Nelson, Jennifer& Barlow, Kristen& Beck, D. Olin& Berbert, Amanda& Eshenroder, Nathan& Francom, Lyndee…[et al.]. 2012. Synergistic Effects of Secretory Phospholipase A2 from the Venom of Agkistrodon piscivorus piscivorus with Cancer Chemotherapeutic Agents. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004604
Modern Language Association (MLA)
Nelson, Jennifer…[et al.]. Synergistic Effects of Secretory Phospholipase A2 from the Venom of Agkistrodon piscivorus piscivorus with Cancer Chemotherapeutic Agents. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1004604
American Medical Association (AMA)
Nelson, Jennifer& Barlow, Kristen& Beck, D. Olin& Berbert, Amanda& Eshenroder, Nathan& Francom, Lyndee…[et al.]. Synergistic Effects of Secretory Phospholipase A2 from the Venom of Agkistrodon piscivorus piscivorus with Cancer Chemotherapeutic Agents. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004604