Sex-Associated Expression of Co-Stimulatory Molecules CD80, CD86, and Accessory Molecules, PDL-1, PDL-2 and MHC-II, in F480+ Macrophages during Murine Cysticercosis
Joint Authors
Nava-Castro, Karen
Morales-Montor, Jorge
Togno-Peirce, Cristián
Terrazas, Luis I.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Macrophages are critically involved in the interaction between T.
crassiceps and the murine host immune system.
Also, a strong gender-associated susceptibility to murine cysticercosis has been reported.
Here, we examined the sex-associated expression of molecules MHC-II, CD80, CD86, PD-L1, and PD-L2 on peritoneal F4/80hi macrophages of BALB/c mice infected with Taenia crassiceps.
Peritoneal macrophages from both sexes of mice were exposed to T.
crassiceps total extract (TcEx).
BALB/c Females mice recruit higher number of macrophages to the peritoneum.
Macrophages from infected animals show increased expression of PDL2 and CD80 that was dependent from the sex of the host.
These findings suggest that macrophage recruitment at early time points during T.
crassiceps infection is a possible mechanism that underlies the differential sex-associated susceptibility displayed by the mouse gender.
American Psychological Association (APA)
Togno-Peirce, Cristián& Nava-Castro, Karen& Terrazas, Luis I.& Morales-Montor, Jorge. 2013. Sex-Associated Expression of Co-Stimulatory Molecules CD80, CD86, and Accessory Molecules, PDL-1, PDL-2 and MHC-II, in F480+ Macrophages during Murine Cysticercosis. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004614
Modern Language Association (MLA)
Togno-Peirce, Cristián…[et al.]. Sex-Associated Expression of Co-Stimulatory Molecules CD80, CD86, and Accessory Molecules, PDL-1, PDL-2 and MHC-II, in F480+ Macrophages during Murine Cysticercosis. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004614
American Medical Association (AMA)
Togno-Peirce, Cristián& Nava-Castro, Karen& Terrazas, Luis I.& Morales-Montor, Jorge. Sex-Associated Expression of Co-Stimulatory Molecules CD80, CD86, and Accessory Molecules, PDL-1, PDL-2 and MHC-II, in F480+ Macrophages during Murine Cysticercosis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004614