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Cytokeratin 18 Is Not Required for Morphogenesis of Developing Prostates but Contributes to Adult Prostate Regeneration
Joint Authors
Zhang, Chenlu
Guo, Yanjing
Cui, Jian
Zhu, Helen He
Gao, Wei-Qiang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytokeratin 18 (CK18) is a key component of keratin-containing intermediate filaments and has long been used as a classic luminal cell marker in prostatic tissue.
However, the in vivo function of CK18 in prostate is not known so far.
We reported in this study, unexpectedly, that deletion of CK18 in a mouse model did not affect the morphological or the histological structures of adult prostate, as the CK18 knockout prostate displayed a normal glandular ductal structure, branching pattern, and composition of both luminal and basal cells.
However, CK18 loss compromised the regenerative tubular branching in dorsolateral prostate after castration and androgen replacement.
Therefore, in contrast to its importance as luminal cell marker, CK18 is dispensable for the prostate morphogenesis but contributes to adult prostate regeneration.
American Psychological Association (APA)
Zhang, Chenlu& Guo, Yanjing& Cui, Jian& Zhu, Helen He& Gao, Wei-Qiang. 2013. Cytokeratin 18 Is Not Required for Morphogenesis of Developing Prostates but Contributes to Adult Prostate Regeneration. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004627
Modern Language Association (MLA)
Zhang, Chenlu…[et al.]. Cytokeratin 18 Is Not Required for Morphogenesis of Developing Prostates but Contributes to Adult Prostate Regeneration. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004627
American Medical Association (AMA)
Zhang, Chenlu& Guo, Yanjing& Cui, Jian& Zhu, Helen He& Gao, Wei-Qiang. Cytokeratin 18 Is Not Required for Morphogenesis of Developing Prostates but Contributes to Adult Prostate Regeneration. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004627