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CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer
Joint Authors
Antczak, Adam
Pastuszak-Lewandoska, Dorota
Górski, Paweł
Domańska, Daria
Migdalska-Sęk, Monika
Czarnecka, Karolina
Nawrot, Ewa
Kordiak, Jacek
Brzeziańska, Ewa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a potent immunoregulatory molecule that downregulates T-cell activation and thus influences the antitumor immune response.
CTLA-4 polymorphisms are associated with various cancers, and CTLA-4 mRNA/protein increased expression is found in several tumor types.
However, most of the studies are based on peripheral blood mononuclear cells, and much less is known about the relationship between CTLA-4 expression, especially gene expression, and its polymorphic variants in cancer tissue.
In our study we assessed the distribution of CTLA-4 two polymorphisms (+49A/G and −318C/T), using TaqMan probes (rs231775 and rs5742909, resp.), and CTLA-4 gene expression in real-time PCR assay in non-small-cell lung cancer (NSCLC) tissue samples.
The increased CTLA-4 expression was observed in the majority of NSCLC patients, and it was significantly correlated with TT genotype (−318C/T) and with tumor size (T2 versus T3 + T4).
The presence of G allele and GG genotype in cancer tissue (+49A/G) was significantly associated with the increased NSCLC risk.
Additionally, we compared genotype distributions in the corresponding tumor and blood samples and found statistically significant differences.
The shift from one genotype in the blood to another in the tumor may confirm the complexity of gene functionality in cancer tissue.
American Psychological Association (APA)
Antczak, Adam& Pastuszak-Lewandoska, Dorota& Górski, Paweł& Domańska, Daria& Migdalska-Sęk, Monika& Czarnecka, Karolina…[et al.]. 2013. CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004629
Modern Language Association (MLA)
Antczak, Adam…[et al.]. CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004629
American Medical Association (AMA)
Antczak, Adam& Pastuszak-Lewandoska, Dorota& Górski, Paweł& Domańska, Daria& Migdalska-Sęk, Monika& Czarnecka, Karolina…[et al.]. CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004629