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Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update
Joint Authors
Guo, Yuan
Lu, Nonghua
Bai, Aiping
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently advanced, while it is still challenged with high morbidity and poor prognosis.
Infliximab, a monoclonal antibody of tumor necrosis factor (TNF), has emerged as an efficient treatment with many clinical benefits such as quick disease activity reduction and IBD patient life quality improvement.
However, the biological effects of infliximab on IBD need to be elucidated.
This paper reviewed the clinical use and recently advanced biological action of infliximab on IBD.
By forming the stable complex with the soluble or the membrane form of TNF in fluid environment or on cell surface of immune cell, fibroblast, endothelium, and epithelium, infliximab quenches TNF activity and performs the important biological actions which lead to amelioration and remission of immune responses.
The mechanisms of infliximab treatment for IBD were intensively discussed.
The recent advances on two topics including predictors and side effects of infliximab treatment were also reviewed.
American Psychological Association (APA)
Guo, Yuan& Lu, Nonghua& Bai, Aiping. 2013. Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004640
Modern Language Association (MLA)
Guo, Yuan…[et al.]. Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004640
American Medical Association (AMA)
Guo, Yuan& Lu, Nonghua& Bai, Aiping. Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004640