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Gene Entropy-Fractal Dimension Informatics with Application to Mouse-Human Translational Medicine
Joint Authors
Tremberger, G.
Holden, T.
Cheung, T.
Ye, J.
Lieberman, D.
Cheung, E.
Dehipawala, S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
DNA informatics represented by Shannon entropy and fractal dimension have been used to form 2D maps of related genes in various mammals.
The distance between points on these maps for corresponding mRNA sequences in different species is used to study evolution.
By quantifying the similarity of genes between species, this distance might be indicated when studies on one species (mouse) would tend to be valid in the other (human).
The hypothesis that a small distance from mouse to human could facilitate mouse to human translational medicine success is supported by the studied ESR-1, LMNA, Myc, and RNF4 sequences.
ID1 and PLCZ1 have larger separation.
The collinearity of displacement vectors is further analyzed with a regression model, and the ID1 result suggests a mouse-chimp-human translational medicine approach.
Further inference was found in the tumor suppression gene, p53, with a new hypothesis of including the bovine PKM2 pathways for targeting the glycolysis preference in many types of cancerous cells, consistent with quantum metabolism models.
The distance between mRNA and protein coding CDS is proposed as a measure of the pressure associated with noncoding processes.
The Y-chromosome DYS14 in fetal micro chimerism that could offer protection from Alzheimer's disease is given as an example.
American Psychological Association (APA)
Holden, T.& Cheung, E.& Dehipawala, S.& Ye, J.& Tremberger, G.& Lieberman, D.…[et al.]. 2013. Gene Entropy-Fractal Dimension Informatics with Application to Mouse-Human Translational Medicine. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004642
Modern Language Association (MLA)
Holden, T.…[et al.]. Gene Entropy-Fractal Dimension Informatics with Application to Mouse-Human Translational Medicine. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004642
American Medical Association (AMA)
Holden, T.& Cheung, E.& Dehipawala, S.& Ye, J.& Tremberger, G.& Lieberman, D.…[et al.]. Gene Entropy-Fractal Dimension Informatics with Application to Mouse-Human Translational Medicine. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004642