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Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
Joint Authors
Olavarria, Jaime F.
Laing, Robyn J.
Lasiene, Jurate
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is known that retinal input is necessary for the normal development of striate cortex and its corticocortical connections, but there is little information on the role that retinal input plays in the development of retinotopically organized connections between V1 and surrounding visual areas.
In nearly all lateral extrastriate areas, the anatomical and physiological representation of the nasotemporal axis of the visual field mirrors the representation of this axis in V1.
To determine whether the mediolateral topography of striate-extrastriate projections is preserved in neonatally enucleated rats, we analyzed the patterns of projections resulting from tracer injections placed at different sites along the mediolateral axis of V1.
We found that the correlation between the distance from injection sites to the lateral border of V1 and the distance of the labeling patterns in area 18a was strong in controls and much weaker in enucleates.
Data from pairs of injections in the same animal revealed that the separation of area 18a projection fields for a given separation of injection sites was more variable in enucleated than in control rats.
Our analysis of single and double tracer injections suggests that neonatal bilateral enucleation weakens, but not completely abolishes, the mediolateral topography in area 18a.
American Psychological Association (APA)
Laing, Robyn J.& Lasiene, Jurate& Olavarria, Jaime F.. 2013. Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004679
Modern Language Association (MLA)
Laing, Robyn J.…[et al.]. Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004679
American Medical Association (AMA)
Laing, Robyn J.& Lasiene, Jurate& Olavarria, Jaime F.. Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004679