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The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability
Joint Authors
Arigony, Ana Lúcia Vargas
de Oliveira, Iuri Marques
Machado, Miriana
Bordin, Diana Lilian
Bergter, Lothar
Prá, Daniel
Pêgas Henriques, João Antonio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Micronutrients, including minerals and vitamins, are indispensable to DNA metabolic pathways and thus are as important for life as macronutrients.
Without the proper nutrients, genomic instability compromises homeostasis, leading to chronic diseases and certain types of cancer.
Cell-culture media try to mimic the in vivo environment, providing in vitro models used to infer cells' responses to different stimuli.
This review summarizes and discusses studies of cell-culture supplementation with micronutrients that can increase cell viability and genomic stability, with a particular focus on previous in vitro experiments.
In these studies, the cell-culture media include certain vitamins and minerals at concentrations not equal to the physiological levels.
In many common culture media, the sole source of micronutrients is fetal bovine serum (FBS), which contributes to only 5–10% of the media composition.
Minimal attention has been dedicated to FBS composition, micronutrients in cell cultures as a whole, or the influence of micronutrients on the viability and genetics of cultured cells.
Further studies better evaluating micronutrients' roles at a molecular level and influence on the genomic stability of cells are still needed.
American Psychological Association (APA)
Arigony, Ana Lúcia Vargas& de Oliveira, Iuri Marques& Machado, Miriana& Bordin, Diana Lilian& Bergter, Lothar& Prá, Daniel…[et al.]. 2013. The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability. BioMed Research International،Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-1004690
Modern Language Association (MLA)
Arigony, Ana Lúcia Vargas…[et al.]. The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability. BioMed Research International No. 2013 (2013), pp.1-22.
https://search.emarefa.net/detail/BIM-1004690
American Medical Association (AMA)
Arigony, Ana Lúcia Vargas& de Oliveira, Iuri Marques& Machado, Miriana& Bordin, Diana Lilian& Bergter, Lothar& Prá, Daniel…[et al.]. The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-1004690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004690