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Alkaline Phosphatase: The Next Independent Predictor of the Poor 90-Day Outcome in Alcoholic Hepatitis
Joint Authors
Szczerbinski, Mariusz
Kasztelan-Szczerbinska, Beata
Celinski, Krzysztof
Slomka, Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Determination of risk factors relevant to 90-day prognosis in AH.
Comparison of the conventional prognostic models such as Maddrey’s modified discriminant function (mDF) and Child-Pugh-Turcotte (CPT) score with newer ones: the Glasgow Alcoholic Hepatitis Score (GAHS); Age, Bilirubin, INR, Creatinine (ABIC) score, Model for End-Stage Liver Disease (MELD), and MELD-Na in the death prediction.
Patients and Methods.
The clinical and laboratory variables obtained at admission were assessed.
The mDF, CPT, GAHS, ABIC, MELD, and MELD-Na scores’ different areas under the curve (AUCs) and the best threshold values were compared.
Logistic regression was used to assess predictors of the 90-day outcome.
Results.
One hundred sixteen pts fulfilled the inclusion criteria.
Twenty (17.4%) pts died and one underwent orthotopic liver transplantation (OLT) within 90 days of follow-up.
No statistically significant differences in the models‘ performances were found.
Multivariate logistic regression identified CPT score, alkaline phosphatase (AP) level higher than 1.5 times the upper limit of normal (ULN), and corticosteroids (CS) nonresponse as independent predictors of mortality.
Conclusions.
The CPT score, AP > 1.5 ULN, and the CS nonresponse had an independent impact on the 90-day survival in AH.
Accuracy of all studied scoring systems was comparable.
American Psychological Association (APA)
Kasztelan-Szczerbinska, Beata& Slomka, Maria& Celinski, Krzysztof& Szczerbinski, Mariusz. 2013. Alkaline Phosphatase: The Next Independent Predictor of the Poor 90-Day Outcome in Alcoholic Hepatitis. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004724
Modern Language Association (MLA)
Kasztelan-Szczerbinska, Beata…[et al.]. Alkaline Phosphatase: The Next Independent Predictor of the Poor 90-Day Outcome in Alcoholic Hepatitis. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004724
American Medical Association (AMA)
Kasztelan-Szczerbinska, Beata& Slomka, Maria& Celinski, Krzysztof& Szczerbinski, Mariusz. Alkaline Phosphatase: The Next Independent Predictor of the Poor 90-Day Outcome in Alcoholic Hepatitis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004724